F
IPR051163

Sodium:Solute Symporter (SSF)
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameSodium:Solute_Symporter_SSF
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The Sodium:Solute Symporter (SSF) family is involved in the electrogenic transport of various substrates across cell membranes, utilizing a sodium gradient as the driving force. Members of this family transport a diverse range of molecules, including multivitamins (biotin, pantothenate), monocarboxylates (lactate, pyruvate, short-chain fatty acids), and inorganic ions (iodide, chloride, bromide, nitrate). The transport process is typically coupled to the co-transport of sodium ions, often with specific stoichiometries, which can be either 2:1 or 4:1 Na+:substrate. This family plays essential roles in nutrient uptake in the intestine, maintaining intestinal mucosa integrity, thyroid function through iodide transport, and energy status in neurons by transporting ketone bodies and lactate. Some members also have a regulatory role in cancer cell proliferation.
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