IPR051178
TfdA dioxygenase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | TfdA_dioxygenase AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The TfdA dioxygenase family is involved in various oxidative decarboxylation and hydroxylation reactions that are crucial for the metabolism of diverse substrates, including herbicides, fatty acids, and purines. Members of this family play roles in the biosynthesis of isonitrile lipopeptides, which are implicated in virulence and metal acquisition in mycobacteria, and in the degradation of phenoxypropionate herbicides. They also participate in the biosynthesis of antibiotics like pentalenolactone and diterpene glucosides such as brassicicene C and fusicoccins. These enzymes typically require Fe(2+) and alpha-ketoglutarate to catalyze the oxidation of their respective substrates, producing compounds like uric acid from xanthine. Activity regulation is observed with ascorbate activation and inhibition by various divalent cations and specific inhibitors.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR43779