F
IPR051188

PHD-type Zinc Finger Domain-Containing Protein
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short namePHD-type_Zinc_Finger
AI

Description

AI-generatedUnreviewed
This family of proteins includes regulators of transcription and ubiquitination processes. Members are involved in the regulation of Th1-type cytokine gene expression, which suggests a role in immune response modulation. Some proteins within this family function as E3 ubiquitin-protein ligases, accepting ubiquitin from E2 enzymes and transferring it to substrates, which is essential for preventing apoptotic cell death during early embryogenesis. Other members act as transcriptional regulators, with specific proteins suppressing ribosomal RNA transcription, potentially influencing ribosome biogenesis. Additionally, certain proteins may be involved in spermatogenesis, indicating a role in reproductive biology. The presence of PHD-type zinc fingers in these proteins suggests a role in chromatin-mediated transcriptional regulation, DNA binding, or protein-protein interactions.

Cross References

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