IPR051327
Multi Antimicrobial Extrusion Protein MepA AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | MATE_MepA_subfamily AI |
Description
AI-generatedUnreviewed
The MepA subfamily of the multi antimicrobial extrusion (MATE) family is comprised of multidrug resistance efflux proteins. Members of the MepA subfamily are involved in the active transport of a variety of clinically relevant antimicrobial agents, including monovalent and divalent biocides, as well as fluoroquinolone antibiotics like norfloxacin and ciprofloxacin. These proteins play a crucial role in bacterial resistance by expelling toxic compounds out of the cell, thereby reducing their intracellular concentration and effectiveness. The MepA subfamily is also implicated in the regulation of virulence factors, as it is required for the transcription of agr and RNAIII, and influences the production of protein A and several toxins in Staphylococcus species.
Contributing Member Database Entry
- PANTHER:PTHR43823