IPR051838
Intracellular mono-ADP-ribosyltransferase ARTD/PARP AI
InterPro entry
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Short name | ARTD_PARP AI |
Description
AI-generatedUnreviewed
The ARTD/PARP family comprises intracellular mono-ADP-ribosyltransferases involved in various cellular processes such as protein translation, stress responses, and unfolded protein response (UPR). Members of the family modify target proteins through mono-ADP-ribosylation, a post-translational modification that can regulate protein function and signaling pathways. Some family members, like PARP16, are known to inhibit protein translation by modifying ribosomal subunits, influence UPR by activating key effectors, and may be involved in cellular responses to amino acid starvation by promoting the formation of stress assemblies. The family is characterized by a conserved domain structure, including a regulatory PARP alpha-helical domain in some members, which can autoinhibit activity in the absence of specific signals.
Cross References
ENZYME
Contributing Member Database Entry
- PANTHER:PTHR21328