F
IPR051849

Glycosaminoglycan-degrading sulfatase
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameGAG-degrading_sulfatase
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
This family of proteins includes enzymes with sulfatase activity, which are involved in the degradation of glycosaminoglycans such as chondroitin sulfate, dermatan sulfate, and heparan sulfate. They catalyze the hydrolysis of sulfate groups, particularly the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues. These enzymes exhibit a preference for heparan sulfate-derived structures and act selectively on 2-sulfoglucuronate, without activity against 2-sulfoiduronate. Their function is essential in various biological processes, including the persistence of gut symbionts in the gastrointestinal tract and the regulation of cellular signaling pathways mediated by sulfated molecules.

Cross References

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