IPR051849
Glycosaminoglycan-degrading sulfatase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | GAG-degrading_sulfatase AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
This family of proteins includes enzymes with sulfatase activity, which are involved in the degradation of glycosaminoglycans such as chondroitin sulfate, dermatan sulfate, and heparan sulfate. They catalyze the hydrolysis of sulfate groups, particularly the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues. These enzymes exhibit a preference for heparan sulfate-derived structures and act selectively on 2-sulfoglucuronate, without activity against 2-sulfoiduronate. Their function is essential in various biological processes, including the persistence of gut symbionts in the gastrointestinal tract and the regulation of cellular signaling pathways mediated by sulfated molecules.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR46615
Representative structure
5g2u: Structure of BT1596,a 2-O GAG sulfatase