F
IPR051932

Bacterial Stress Response Regulators
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameBact_StressResp_Reg
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Description

AI-generatedUnreviewed
The protein family is involved in the environmental signaling branch of the general stress response in bacteria. Members of the family include blue-light photoreceptors that share spectroscopical features with plant phototropins and are involved in the reversible formation of a blue-shifted photoproduct. This photoproduct is assigned to an FMN-cysteine thiol adduct and plays a role in regulating the activity of the general stress transcription factor sigma-B. Other members, RsbR paralogs (RsbRA, RsbRB, RsbRC, RsbRD), and RsbS, interact with sigma-B through a phosphorylation-dependent mechanism. Non-phosphorylated RsbS and one of the RsbR paralogs sequester RsbT, a negative regulator of sigma-B. Upon phosphorylation, RsbS and the RsbR paralogs release RsbT, which then activates RsbU, leading to the positive regulation of sigma-B in response to stress. The precise functions of some members remain undetermined, and one member is uncharacterized.
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