F
IPR052020

Cyclic di-GMP and 3'3'-cGAMP-specific phosphodiesterases
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameCyclic_di-GMP/3'3'-cGAMP_PDE
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Description

AI-generatedUnreviewed
This family of proteins includes cyclic di-GMP and 3'3'-cGAMP-specific phosphodiesterases. They are involved in the hydrolysis of cyclic dinucleotides, such as cyclic diguanylate (c-di-GMP) and 3'3'-cyclic GMP-AMP (3'3'-cGAMP), to linear nucleotides. These enzymes play key roles in bacterial signaling pathways, regulating processes such as motility, biofilm formation, and virulence. They act by modulating the levels of cyclic dinucleotides within the cell, which serve as secondary messengers. Some family members are regulated by metal ion binding or phosphorylation, which affects their catalytic activity. The proteins may contain specific domains, such as HD-GYP, that are crucial for their function and interaction with other proteins.

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