F
IPR052112

EGFR Signaling Regulator Kinase
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameEGFR_SigReg_Kinase
AI

Description

AI-generatedUnreviewed
The protein family includes non-receptor tyrosine-protein and serine/threonine-protein kinases involved in cell signaling, particularly in relation to EGFR. The family members are implicated in various cellular processes such as cell spreading, migration, survival, growth, and proliferation. They act as downstream effectors of CDC42, mediating cell migration and influencing synaptic function and brain development. The kinases phosphorylate a range of substrates, including AKT1, AR, and WWOX, playing roles in endocytosis, ubiquitination, and tumor growth regulation. Additionally, the family encompasses negative regulators of EGFR signaling, which inhibit EGFR catalytic activity and autophosphorylation, affecting keratinocyte proliferation, differentiation, and responses to steroid hormones.

Cross References

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