F
IPR052804

Ubiquitin-editing complex component
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameUEC_component
AI

Description

AI-generatedUnreviewed
This family of proteins is involved in the regulation of inflammatory signaling pathways. Members of this family act as essential components of a ubiquitin-editing protein complex, which includes TNFAIP3, ITCH, and TAX1BP1. They play a role in ensuring the transient nature of the signaling pathways by promoting the association of TNFAIP3 with RIPK1 following TNF stimulation. They facilitate the deubiquitination of 'Lys-63' polyubiquitin chains on RIPK1 and the subsequent formation of 'Lys-48'-linked polyubiquitin chains, leading to the proteasomal degradation of RIPK1. This activity effectively terminates the activation of NF-kappa-B mediated by TNF or LPS. Additionally, these proteins are involved in recruiting STAMBP to the E3 ubiquitin-ligase SMURF2, targeting it for ubiquitination and subsequent degradation by the 26S proteasome. They also contain a PPxY motif, which is known to mediate interactions with the NEDD4 E3 ubiquitin ligase.
Contributing Member Database Entry
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