F
IPR053384

SAM-dependent methyltransferase
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameSAM-dep_methyltransferase
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
This family of proteins includes enzymes that function as methyltransferases, utilizing S-adenosyl-L-methionine (SAM) as the methyl donor to transfer methyl groups to various substrates. Members of this family are involved in the methylation of small molecules such as nicotinamide, phenylethanolamine, and indolethylamine, which are important in metabolic pathways, neurotransmitter synthesis, and detoxification processes. These enzymes play key roles in regulating cellular methylation potential, epigenetic and transcriptional changes, energy expenditure, gluconeogenesis, cholesterol biosynthesis, and the salvage pathway of NAD(+) synthesis. They also contribute to the detoxification of xenobiotics and selenium compounds. Some family members are involved in the synthesis of hormones such as adrenaline from noradrenaline and are implicated in the stability of specific deacetylases through their methylation products.

References

1. Biosynthesis of Guanitoxin Enables Global Environmental Detection in Freshwater Cyanobacteria. Lima ST, Fallon TR, Cordoza JL, Chekan JR, Delbaje E, Hopiavuori AR, Alvarenga DO, Wood SM, Luhavaya H, Baumgartner JT, Dorr FA, Etchegaray A, Pinto E, McKinnie SMK, Fiore MF, Moore BS. J Am Chem Soc 144, 9372-9379, (2022). PMID: 35583956

Cross References

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