IPR054071
Neurofibromin, PH domain-like
InterPro entry
Short name | PH_NF1 |
Overlapping homologous superfamilies |
Description
This entry represents the pleckstrin homology (PH)-like domain of neurofibromin (NF1) and similar sequences from animals and fungi. Neurofibromin is a Ras-specific GTPase-activating protein (RasGAP). Mutations in the gene encoding this protein cause neurofibromatosis type 1 (NF1). This domain forms a bipartite module with the Sec14p homologous segment, which together exhibit phospholipid binding activity. The domain interface architecture suggests a model of how the NF1 PH domain may regulate binding of a ligand by the Sec14 module
[1, 2, 3].
References
1.A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein. D'Angelo I, Welti S, Bonneau F, Scheffzek K. EMBO Rep. 7, 174-9, (2006). View articlePMID: 16397625
2.The structure of neurofibromin isoform 2 reveals different functional states. Naschberger A, Baradaran R, Rupp B, Carroni M. Nature 599, 315-319, (2021). View articlePMID: 34707296
Further reading
4. The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex. Welti S, Fraterman S, D'Angelo I, Wilm M, Scheffzek K. J. Mol. Biol. 366, 551-62, (2007). View articlePMID: 17187824
Contributing Member Database Entry
- Pfam:PF21877