D
IPR054762

Terminase, large subunit, ribonuclease H-like domain

InterPro entry
Short nameGp19_RNaseH-like

Description

This entry represents the C-terminal ribonuclease (RNase) H-like domain in the terminase, large subunit from Escherichia phage T7 (Gp19), which functions as an ATP-powered molecular motor essential for the translocation of viral DNA into empty capsids. It also acts as an endonuclease, cleaving the viral genome at a specific and precise double-stranded DNA sequence to initiate and conclude the packaging process
[1]
. Members of this group are found in tailed bacteriophages and bacterial prophages.

References

1.Large terminase conformational change induced by connector binding in bacteriophage T7. Dauden MI, Martin-Benito J, Sanchez-Ferrero JC, Pulido-Cid M, Valpuesta JM, Carrascosa JL. J Biol Chem 288, 16998-7007, (2013). PMID: 23632014

Cross References

Contributing Member Database Entry
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