D
IPR055060

Acyl-CoA oxidase, C-alpha1 domain

InterPro entry
Short nameACOX_C_alpha1
Overlapping
homologous
superfamilies
 

Description

This entry represents the C-alpha1 domain from acyl-CoA oxidases which has an all-α helical structure that a forms a four α-helical bundle
[4, 2, 5, 3, 1]
. This domain includes the FAD-binding and substrate-binding sites.

References

1.Structural insight into the substrate specificity of acyl-CoA oxidase1 from Yarrowia lipolytica for short-chain dicarboxylyl-CoAs. Kim S, Kim KJ. Biochem Biophys Res Commun 495, 1628-1634, (2018). View articlePMID: 29198706

2.Acyl-CoA oxidase 1 from Arabidopsis thaliana. Structure of a key enzyme in plant lipid metabolism. Pedersen L, Henriksen A. J. Mol. Biol. 345, 487-500, (2005). View articlePMID: 15581893

3.Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans. Zhang X, Li K, Jones RA, Bruner SD, Butcher RA. Proc Natl Acad Sci U S A 113, 10055-60, (2016). View articlePMID: 27551084

4.Three-dimensional structure of the flavoenzyme acyl-CoA oxidase-II from rat liver, the peroxisomal counterpart of mitochondrial acyl-CoA dehydrogenase. Nakajima Y, Miyahara I, Hirotsu K, Nishina Y, Shiga K, Setoyama C, Tamaoki H, Miura R. J. Biochem. 131, 365-74, (2002). View articlePMID: 11872165

5.Structure determination and analysis of acyl-CoA oxidase (ACX1) from tomato. Powers RA, Rife CL, Schilmiller AL, Howe GA, Garavito RM. Acta Crystallogr. D Biol. Crystallogr. 62, 683-6, (2006). View articlePMID: 16699197

Cross References

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