IPR000100
Ribonuclease P
InterPro entry
Short name | RNase_P |
Overlapping homologous superfamilies |
Description
Ribonuclease P (
3.1.26.5) (RNase P)
[1, 2, 3] is a site specific endonuclease that generates mature tRNAs by catalysing the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. In bacteria RNase P is known to be composed of two components: a large RNA (about 400 base pairs) encoded by rnpB, and a small protein (119 to 133 amino acids) encoded by rnpA. The RNA moiety of RNase P carries the catalytic activity; the protein component plays an auxiliary, but essential, role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. The sequence of rnpA is not highly conserved, however there is, in the central part of the protein, a conserved basic region.
References
1.Ribonuclease P: function and variation. Pace NR, Smith D. J. Biol. Chem. 265, 3587-90, (1990). View articlePMID: 1689306
2.Ribonuclease P. Postscript. Altman S. J. Biol. Chem. 265, 20053-6, (1990). View articlePMID: 1700778
3.Ribonuclease P RNA and protein subunits from bacteria. Brown JW, Pace NR. Nucleic Acids Res. 20, 1451-6, (1992). View articlePMID: 1374553
GO terms
biological process
molecular function
cellular component
- None
Cross References
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