IPR000133
ER lumen protein retaining receptor
InterPro entry
Short name | ER_ret_rcpt |
Description
Proteins resident in the lumen of the endoplasmic reticulum (ER) contain a C-terminal tetrapeptide, commonly known as Lys-Asp-Glu-Leu (KDEL) in mammals and His-Asp-Glu-Leu (HDEL) in yeast (Saccharomyces cerevisiae) that acts as a signal for their retrieval from subsequent compartments of the secretory pathway. The receptor for this signal is a ~26kDa Golgi membrane protein, initially identified as the ERD2 gene product in S. cerevisiae. The receptor molecule, known variously as the ER lumen protein retaining receptor or the 'KDEL receptor', is believed to cycle between the cis side of the Golgi apparatus and the ER. It has also been characterised in a number of other species, including plants, Plasmodium, Drosophila and mammals. In mammals, 2 highly related forms of the receptor are known.
References
1. Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport. Townsley FM, Wilson DW, Pelham HR. EMBO J. 12, 2821-9, (1993). View articlePMID: 8392934
GO terms
biological process
molecular function
cellular component
Cross References
PROSITE Doc
Representative structure
6i6h: Crystal structure of the KDEL receptor in the peptide bound state