IPR000256
Influenza A virus NS1 protein
InterPro entry
Short name | NS1A |
Overlapping homologous superfamilies | |
family relationships |
Description
NS1 is a homodimeric RNA-binding protein found in influenza virus that is required for viral replication. NS1 binds polyA tails of mRNA keeping them in the nucleus. NS1 inhibits pre-mRNA splicing by tightly binding to a specific stem-bulge of U6 snRNA
[1].
References
1.A novel RNA-binding motif in influenza A virus non-structural protein 1. Chien CY, Tejero R, Huang Y, Zimmerman DE, Rios CB, Krug RM, Montelione GT. Nat. Struct. Biol. 4, 891-5, (1997). View articlePMID: 9360601
GO terms
Cross References
Genome Properties
Contributing Member Database Entry
- Pfam:PF00600