D
IPR000323

Copper type II, ascorbate-dependent monooxygenase, N-terminal

InterPro entry
Short nameCu2_ascorb_mOase_N
Overlapping
homologous
superfamilies
 

Description

Copper type II, ascorbate-dependent monooxygenases
[1]
are a class of enzymes that requires copper as a cofactor and which uses ascorbate as an electron donor. This family contains two related enzymes, dopamine-beta-monooxygenase (
1.14.17.1
) and peptidyl-glycine alpha-amidating monooxygenase (
1.14.17.3
). There are a few regions of sequence similarities between these two enzymes, two of these regions contain clusters of conserved histidine residues which are most probably involved in binding copper.

References

1.Sequence similarity between dopamine beta-hydroxylase and peptide alpha-amidating enzyme: evidence for a conserved catalytic domain. Southan C, Kruse LI. FEBS Lett. 255, 116-20, (1989). View articlePMID: 2792366

GO terms

Cross References

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