IPR000323
Copper type II, ascorbate-dependent monooxygenase, N-terminal
InterPro entry
Short name | Cu2_ascorb_mOase_N |
Overlapping homologous superfamilies |
Description
Copper type II, ascorbate-dependent monooxygenases
[1] are a class of enzymes that requires copper as a cofactor and which uses ascorbate as an electron donor. This family contains two related enzymes, dopamine-beta-monooxygenase (
1.14.17.1) and peptidyl-glycine alpha-amidating monooxygenase (
1.14.17.3). There are a few regions of sequence similarities between these two enzymes, two of these regions contain clusters of conserved histidine residues which are most probably involved in binding copper.
References
1.Sequence similarity between dopamine beta-hydroxylase and peptide alpha-amidating enzyme: evidence for a conserved catalytic domain. Southan C, Kruse LI. FEBS Lett. 255, 116-20, (1989). View articlePMID: 2792366
GO terms
biological process
- None
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- Pfam:PF01082