F
IPR000343

Glutamyl-tRNA reductase

InterPro entry
Short name4pyrrol_synth_GluRdtase
Overlapping
homologous
superfamilies
 

Description

Delta-aminolevulinic acid (ALA) is the obligatory precursor for the synthesis of all tetrapyrroles including porphyrin derivatives such as chlorophyll and heme. ALA can be synthesized via two different pathways: the Shemin (or C4) pathway which involves the single step condensation of succinyl-CoA and glycine and which is catalyzed by ALA synthase and via the C5 pathway from the five-carbon skeleton of glutamate. The C5 pathway operates in the chloroplast of plants and algae, in cyanobacteria, in some eubacteria and in archaebacteria
[2]
.

The initial step in the C5 pathway is carried out by glutamyl-tRNA reductase (GluTR) which catalyzes the NADP-dependent conversion of glutamate- tRNA(Glu) to glutamate-1-semialdehyde (GSA) with the concomitant release of tRNA(Glu) which can then be recharged with glutamate by glutamyl-tRNA synthetase
[2]
.

This entry represents glutamyl-tRNA reductase (
1.2.1.70
), which required NADPH as a coenzyme
[1, 2]
. This entry also includes the multifunctional siroheme biosynthesis protein HemA fromClostridium josuiwhich besides acting as a glutamyl-tRNA reductase also converts precorrin-2 to sirohydrochlorin and sirohydrochlorin to siroheme
[3]
.

References

1.Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum. Raux E, Schubert HL, Warren MJ. Cell. Mol. Life Sci. 57, 1880-93, (2000). View articlePMID: 11215515

2.Glutamyl-transfer RNA: a precursor of heme and chlorophyll biosynthesis. Jahn D, Verkamp E, Soll D. Trends Biochem. Sci. 17, 215-8, (1992). View articlePMID: 1502723

3.Cloning and sequencing of some genes responsible for porphyrin biosynthesis from the anaerobic bacterium Clostridium josui. Fujino E, Fujino T, Karita S, Sakka K, Ohmiya K. J. Bacteriol. 177, 5169-75, (1995). View articlePMID: 7665501

GO terms

Cross References

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