D
IPR000472

Activin types I and II receptor domain

InterPro entry
Short nameActivin_recp
Overlapping
homologous
superfamilies
 

Description

This is a hydrophilic cysteine-rich ligand-binding domain found in both TGF-beta receptor types (type I and II). In both types, this domain posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box
[2, 3, 1]
.

The Transforming growth factor-beta superfamily of ligands include: bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), anti-mullerian hormone (AMH), activin, nodal and TGF-beta. Signalling begins with the binding of a TGF-beta superfamily ligand to a TGF-beta type II receptors. The type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators
[5]
.

The receptors for most of the members of this growth factor family are related. They are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain
[6, 4, 7]
.

References

1.Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. ten Dijke P, Ichijo H, Franzen P, Schulz P, Saras J, Toyoshima H, Heldin CH, Miyazono K. Oncogene 8, 2879-87, (1993). PMID: 8397373

2.From receptor to nucleus: the Smad pathway. Baker JC, Harland RM. Curr. Opin. Genet. Dev. 7, 467-73, (1997). View articlePMID: 9309176

3.The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Kingsley DM. Genes Dev. 8, 133-46, (1994). View articlePMID: 8299934

4.Mechanism of activation of the TGF-beta receptor. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J. Nature 370, 341-7, (1994). View articlePMID: 8047140

5.TGF-beta signal transduction. Massague J. Annu. Rev. Biochem. 67, 753-91, (1998). View articlePMID: 9759503

6.Signal transduction by members of the transforming growth factor-beta superfamily. Attisano L, Wrana JL. Cytokine Growth Factor Rev. 7, 327-39, (1996). View articlePMID: 9023056

7.Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals. Massague J, Weis-Garcia F. Cancer Surv. 27, 41-64, (1996). PMID: 8909794

GO terms

Cross References

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.