D
IPR000494

Receptor L-domain

InterPro entry
Short nameRcpt_L-dom
Overlapping
homologous
superfamilies
 

Description

The structure for the first three domains of the extracellular portion of IGF-1R (type-1 insulin-like growth-factor receptor) has been solved and consists of two L-domains and a cysteine rich region (L1-Cys-rich-L2). The L-domains each consist of a single-stranded right-handed β-helix. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain with modules associated in an unusual manner. The three domains surround a central space of sufficient size to accommodate a ligand molecule
[2]
.

This entry represents the L-domain. This domain can also be found in insulin receptor(IR) and epidermal growth-factor receptor (EGFR) family members, and in yeast cell surface GPI proteins PST1 and ECM33
[1]
.

References

1.PST1 and ECM33 encode two yeast cell surface GPI proteins important for cell wall integrity. Pardo M, Monteoliva L, Vazquez P, Martinez R, Molero G, Nombela C, Gil C. Microbiology (Reading, Engl.) 150, 4157-70, (2004). View articlePMID: 15583168

2.Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor. Garrett TP, McKern NM, Lou M, Frenkel MJ, Bentley JD, Lovrecz GO, Elleman TC, Cosgrove LJ, Ward CW. Nature 394, 395-9, (1998). View articlePMID: 9690478

Cross References

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