IPR000494
Receptor L-domain
InterPro entry
Short name | Rcpt_L-dom |
Overlapping homologous superfamilies |
Description
The structure for the first three domains of the extracellular portion of IGF-1R (type-1 insulin-like growth-factor receptor) has been solved and consists of two L-domains and a cysteine rich region (L1-Cys-rich-L2). The L-domains each consist of a single-stranded right-handed β-helix. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain with modules associated in an unusual manner. The three domains surround a central space of sufficient size to accommodate a ligand molecule
[2].
This entry represents the L-domain. This domain can also be found in insulin receptor(IR) and epidermal growth-factor receptor (EGFR) family members, and in yeast cell surface GPI proteins PST1 and ECM33
[1].
References
1.PST1 and ECM33 encode two yeast cell surface GPI proteins important for cell wall integrity. Pardo M, Monteoliva L, Vazquez P, Martinez R, Molero G, Nombela C, Gil C. Microbiology (Reading, Engl.) 150, 4157-70, (2004). View articlePMID: 15583168
2.Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor. Garrett TP, McKern NM, Lou M, Frenkel MJ, Bentley JD, Lovrecz GO, Elleman TC, Cosgrove LJ, Ward CW. Nature 394, 395-9, (1998). View articlePMID: 9690478
Cross References
ENZYME
Contributing Member Database Entry
- Pfam:PF01030
Representative structure
8jyr: Crystal structure of anti-HER2 antibody H2Mab-119 in complex with HER2 domain I