IPR000669
Mannitol dehydrogenase
InterPro entry
Short name | Mannitol_DH |
Overlapping homologous superfamilies | |
family relationships |
Description
Mannitol dehydrogenases catalyse the NAD-dependent reduction of mannitol-1-phosphates as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glycolytic intermediates
[1]. Mannitol 2-dehydrogenase catalyses the NAD-dependent reduction of mannitol to fructose
[2].
Several dehydrogenases have been shown
[2] to be evolutionary related, including mannitol-1-phosphate 5-dehydrogenase (
1.1.1.17) (gene mtlD), mannitol 2-dehydrogenase (
1.1.1.67) (gene mtlK); mannonate oxidoreductase (
1.1.1.57) (fructuronate reductase) (gene uxuB); Escherichia coli hypothetical proteins ydfI and yeiQ; and yeast hypothetical protein YEL070w.
References
1.Isolation, characterization, and nucleotide sequence of the Streptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvate phosphotransferase system. Honeyman AL, Curtiss R 3rd. Infect. Immun. 60, 3369-75, (1992). View articlePMID: 1322373
GO terms
Cross References
Contributing Member Database Entry
- PRINTS:PR00084