D
IPR000697

WH1/EVH1 domain

InterPro entry
Short nameWH1/EVH1_dom
Overlapping
homologous
superfamilies
 
domain relationships

Description

The EVH1 (WH1, RanBP1-WASP) domain is found in multi-domain proteins implicated in a diverse range of signalling, nuclear transport and cytoskeletal events. This domain of around 115 amino acids is present in species ranging from yeast to mammals. Many EVH1-containing proteins associate with actin-based structures and play a role in cytoskeletal organisation. EVH1 domains recognise and bind the proline-rich motif FPPPP with low-affinity, further interactions then form between flanking residues
[1, 2]
.

WASP family proteins contain an EVH1 (WH1) in their N-terminals which bind proline-rich sequences in the WASP interacting protein. Proteins of the RanBP1 family contain a WH1 domain in their N-terminal region, which seems to bind a different sequence motif present in the C-terminal part of RanGTP protein
[3, 4]
.

References

1.EVH1 domains: structure, function and interactions. Ball LJ, Jarchau T, Oschkinat H, Walter U. FEBS Lett. 513, 45-52, (2002). View articlePMID: 11911879

2.A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. Niebuhr K, Ebel F, Frank R, Reinhard M, Domann E, Carl UD, Walter U, Gertler FB, Wehland J, Chakraborty T. EMBO J. 16, 5433-44, (1997). View articlePMID: 9312002

3.EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family. Callebaut I, Cossart P, Dehoux P. FEBS Lett. 441, 181-5, (1998). View articlePMID: 9883880

4.The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif. Beddow AL, Richards SA, Orem NR, Macara IG. Proc. Natl. Acad. Sci. U.S.A. 92, 3328-32, (1995). View articlePMID: 7724562

Further reading

5. Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly. Prehoda KE, Lee DJ, Lim WA. Cell 97, 471-80, (1999). View articlePMID: 10338211

Cross References

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