IPR001173
Glycosyltransferase 2-like
InterPro entry
Short name | Glyco_trans_2-like |
Overlapping homologous superfamilies | |
domain relationships |
Description
This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP-N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids
[2].
The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (
2.4.1.-) and related proteins into distinct sequence based families has been described
[1]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.
References
1.A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities. Campbell JA, Davies GJ, Bulone V, Henrissat B. Biochem. J. 326 ( Pt 3), 929-39, (1997). View articlePMID: 9334165
2.Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance. Sobhanifar S, Worrall LJ, King DT, Wasney GA, Baumann L, Gale RT, Nosella M, Brown ED, Withers SG, Strynadka NC. PLoS Pathog. 12, e1006067, (2016). View articlePMID: 27973583
Cross References
ENZYME
CAZy
Genome Properties
Representative structure
1qgq: UDP-MANGANESE COMPLEX OF SPSA FROM BACILLUS SUBTILIS