IPR001321
Hypoxia-inducible factor-1 alpha
InterPro entry
Short name | HIF-1_alpha |
Description
Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Specifically, they respond to decreases in oxygen, mediating the effects of hypoxia
[2]. HIFs are heterodimers, composed of an alpha and a beta subunit. At least 3 different alpha subunits are known to exist, termed HIF-1, -2 and -3 alpha. Beta subunits, meanwhile, are constitutively-expressed aryl hydrocarbon receptor nuclear translocators (ARNTs).
In addition to their role in hypoxia, HIFs have been shown to be involved in a range of processes, including angiogenesis, metal transport, mitochondrial function and cell growth
[1].
This entry represents the HIF-1 alpha subunit.
References
1.Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. Webb JD, Coleman ML, Pugh CW. Cell. Mol. Life Sci. 66, 3539-54, (2009). View articlePMID: 19756382
2.The human side of hypoxia-inducible factor. Smith TG, Robbins PA, Ratcliffe PJ. Br. J. Haematol. 141, 325-34, (2008). View articlePMID: 18410568
GO terms
biological process
molecular function
cellular component
Contributing Member Database Entry
- PRINTS:PR01080