F
IPR001321

Hypoxia-inducible factor-1 alpha

InterPro entry
Short nameHIF-1_alpha

Description

Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Specifically, they respond to decreases in oxygen, mediating the effects of hypoxia
[2]
. HIFs are heterodimers, composed of an alpha and a beta subunit. At least 3 different alpha subunits are known to exist, termed HIF-1, -2 and -3 alpha. Beta subunits, meanwhile, are constitutively-expressed aryl hydrocarbon receptor nuclear translocators (ARNTs).

In addition to their role in hypoxia, HIFs have been shown to be involved in a range of processes, including angiogenesis, metal transport, mitochondrial function and cell growth
[1]
.

This entry represents the HIF-1 alpha subunit.

References

1.Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. Webb JD, Coleman ML, Pugh CW. Cell. Mol. Life Sci. 66, 3539-54, (2009). View articlePMID: 19756382

2.The human side of hypoxia-inducible factor. Smith TG, Robbins PA, Ratcliffe PJ. Br. J. Haematol. 141, 325-34, (2008). View articlePMID: 18410568

GO terms

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