D
IPR001490

Hepatitis C virus, Non-structural protein NS4b

InterPro entry
Short nameHCV_NS4b

Description

The genome polyprotein contains: caspid protein C, envelope glycoproteins E1 and E2, protein P7, nonstructural protein NS2, protease/helicase NS3, nonstructural proteins NS4A and NS4B (this family), NS5A and NS5B.

The small proteins NS2A, NS2B, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function
[2]
. It is known that NS4B interacts with NS4A and NS3 to form a large replicase complex to direct the viral RNA replication
[1]
. NS3 and NS5 may also play a role in the viral RNA replication.

References

1.The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins. Lin C, Wu JW, Hsiao K, Su MS. J. Virol. 71, 6465-71, (1997). View articlePMID: 9261364

2.The nonstructural proteins of the hepatitis C virus: structure and functions. Neddermann P, Tomei L, Steinkuhler C, Gallinari P, Tramontano A, De Francesco R. Biol. Chem. 378, 469-76, (1997). PMID: 9224925

GO terms

Cross References

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