IPR001490
Hepatitis C virus, Non-structural protein NS4b
InterPro entry
Short name | HCV_NS4b |
Description
The genome polyprotein contains: caspid protein C, envelope glycoproteins E1 and E2, protein P7, nonstructural protein NS2, protease/helicase NS3, nonstructural proteins NS4A and NS4B (this family), NS5A and NS5B.
The small proteins NS2A, NS2B, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function
[2]. It is known that NS4B interacts with NS4A and NS3 to form a large replicase complex to direct the viral RNA replication
[1]. NS3 and NS5 may also play a role in the viral RNA replication.
References
1.The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins. Lin C, Wu JW, Hsiao K, Su MS. J. Virol. 71, 6465-71, (1997). View articlePMID: 9261364
GO terms
biological process
- None
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- Pfam:PF01001