F
IPR001654

Marek's disease glycoprotein A

InterPro entry
Short nameMarek_A
Overlapping
homologous
superfamilies
 
family relationships

Description

Herpesviruses have been implicated as a cause of tumours in a number of species. The common tumour condition of the fowl is caused by Meleagrid herpesvirus 1 (MeHV-1). Although infection is ubiquitous, only a proportion of fowl develop tumours, and the precise details of the process of tumour induction remains to be elucidated. Secretory glycoprotein GP57-65 precursor (glycoprotein A - GA) is thought to play an immunoevasive role in the pathogenesis of Marek's disease. It is a candidate for causing the early-stage immunosuppression that occurs after MDHV infection. The protein is predominantly secreted, but a small amount of mature GP57-65 is anchored in the plasma membrane, or held by other interactions. GA is similar to Herpesvirus glycoprotein C, and belongs to the immunoglobulin gene superfamily
[1, 2]
.

References

1.Structure and complete nucleotide sequence of the Marek's disease herpesvirus gp57-65 gene. Coussens PM, Velicer LF. J. Virol. 62, 2373-9, (1988). View articlePMID: 2836620

2.Nucleotide sequence of the Marek's disease virus (MDV) RB-1B A antigen gene and the identification of the MDV A antigen as the herpes simplex virus-1 glycoprotein C homologue. Binns MM, Ross NL. Virus Res. 12, 371-81, (1989). View articlePMID: 2543160

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