IPR002034
Alpha-isopropylmalate/homocitrate synthase, conserved site
InterPro entry
Short name | AIPM/Hcit_synth_CS |
Description
A number of enzymes have been shown to be functionally as well as evolutionary related
[1]. The nifV and leuA genes encode homocitrate synthase and alpha-isopropylmalate synthase, respectively The N-terminal parts of NifV and LeuA from bacteria are highly similar to each other
[2]. Homocitrate synthase (
2.3.3.14) (gene nifV) is involved in the biosynthesis of the iron-molybdenum cofactor of nitrogenase and catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate into homocitrate. Alpha-isopropylmalate synthase (
2.3.3.13) catalyses the first step in the biosynthesis of leucine, the condensation ofacetyl-CoA and alpha-ketoisovalerate to form 2-isopropylmalate synthase.
References
1.The N-terminal and C-terminal portions of NifV are encoded by two different genes in Clostridium pasteurianum. Wang SZ, Dean DR, Chen JS, Johnson JL. J. Bacteriol. 173, 3041-6, (1991). View articlePMID: 2022611
2.Identification and characterization of the nifV-nifZ-nifT gene region from the filamentous cyanobacterium Anabaena sp. strain PCC 7120. Stricker O, Masepohl B, Klipp W, Bohme H. J. Bacteriol. 179, 2930-7, (1997). View articlePMID: 9139910
GO terms
biological process
molecular function
cellular component
- None