Gamma-aminobutyric-acid A receptor, beta subunit
Short name | GABAAb_rcpt |
Overlapping homologous superfamilies | |
family relationships |
Description
* Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits
* Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits
* Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known
* Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7)
* Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate)
References
1.Structure and gating of the glutamate receptor ion channel. Wollmuth LP, Sobolevsky AI. Trends Neurosci. 27, 321-8, (2004). View articlePMID: 15165736
2.Assembly and trafficking of nicotinic acetylcholine receptors (Review). Millar NS, Harkness PC. Mol. Membr. Biol. 25, 279-92, (2008). View articlePMID: 18446614
3.Molecular structure and function of the glycine receptor chloride channel. Lynch JW. Physiol. Rev. 84, 1051-95, (2004). PMID: 15383648
4.Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. Hadingham KL, Wingrove PB, Wafford KA, Bain C, Kemp JA, Palmer KJ, Wilson AW, Wilcox AS, Sikela JM, Ragan CI. Mol. Pharmacol. 44, 1211-8, (1993). View articlePMID: 8264558
5.Structural features of the ligand-binding domain of the serotonin 5HT3 receptor. Yan D, Schulte MK, Bloom KE, White MM. J. Biol. Chem. 274, 5537-41, (1999). View articlePMID: 10026168
6.Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor. Wagner K, Edson K, Heginbotham L, Post M, Huganir RL, Czernik AJ. J. Biol. Chem. 266, 23784-9, (1991). View articlePMID: 1721053
7.Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing. Kofuji P, Wang JB, Moss SJ, Huganir RL, Burt DR. J. Neurochem. 56, 713-5, (1991). View articlePMID: 1846404
8.Structure and pharmacology of vertebrate GABAA receptor subtypes. Whiting PJ, McKernan RM, Wafford KA. Int. Rev. Neurobiol. 38, 95-138, (1995). PMID: 8537206
9.GABA(A) receptor subtypes: dissecting their pharmacological functions. Rudolph U, Crestani F, Mohler H. Trends Pharmacol. Sci. 22, 188-94, (2001). View articlePMID: 11282419
10.International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ. Pharmacol. Rev. 50, 291-313, (1998). View articlePMID: 9647870
11.theta, a novel gamma-aminobutyric acid type A receptor subunit. Bonnert TP, McKernan RM, Farrar S, le Bourdelles B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ. Proc. Natl. Acad. Sci. U.S.A. 96, 9891-6, (1999). View articlePMID: 10449790
12.Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology. Pritchett DB, Sontheimer H, Shivers BD, Ymer S, Kettenmann H, Schofield PR, Seeburg PH. Nature 338, 582-5, (1989). View articlePMID: 2538761
13.GABA(A) receptors: Subtypes provide diversity of function and pharmacology. Olsen RW, Sieghart W. Neuropharmacology (2008). PMID: 18760291
14.GABA(A)-receptor subtypes: a new pharmacology. Mohler H, Crestani F, Rudolph U. 1, 22-5, (2001). View articlePMID: 11712530
GO terms
biological process
cellular component
Contributing Member Database Entry
- PRINTS:PR01160