D
IPR002532

Hantavirus glycoprotein Gc, N-terminal domain

InterPro entry
Short nameHanta_Gc_N

Description

This entry represents the polyprotein region which forms the N-terminal region of Gc glycoprotein. It has been shown that the N-terminal region of glycoprotein Gc has the conserved CNP motif, suggested to be an integrin-binding motif
[5]
. Gc protein has a typical class II fusion protein fold consisting of a central β-sandwich domain (termed domain I) made of eight β-strands arranged in two antiparallel β-sheets, domain II which has an elongated shape with two subdomains (a central, opened β-barrel proximal to domain I and a distal β-sandwich 'tip'), and domain III, which has an Ig-like fold
[4, 3]
. This entry represents the N-terminal region of Gc containing the central and dimerisation domains (which includes domain I and II).

The medium (M) genome segment of Hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins
[1]
, Gn and Gc (also known as G1 and G2, respectively) as a polyprotein precursor
[4, 3]
. Gn and Gc forms homotetramers at the surface of the virion, which attach the virion to host cell receptors including integrin beta3/ITGB3 and induce internalization, predominantly through clathrin-dependent endocytosis
[3, 2]
.

References

1.Nucleotide sequence of the M segment of the genomic RNA of Hantaan virus 76-118. Yoo DW, Kang CY. Nucleic Acids Res. 15, 6299-300, (1987). View articlePMID: 3114716

2.Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis. Jin M, Park J, Lee S, Park B, Shin J, Song KJ, Ahn TI, Hwang SY, Ahn BY, Ahn K. Virology 294, 60-9, (2002). PMID: 11886265

3.Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc. Guardado-Calvo P, Bignon EA, Stettner E, Jeffers SA, Perez-Vargas J, Pehau-Arnaudet G, Tortorici MA, Jestin JL, England P, Tischler ND, Rey FA. PLoS Pathog. 12, e1005813, (2016). PMID: 27783711

4.The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism. Serris A, Stass R, Bignon EA, Muena NA, Manuguerra JC, Jangra RK, Li S, Chandran K, Tischler ND, Huiskonen JT, Rey FA, Guardado-Calvo P. Cell 183, 442-456.e16, (2020). PMID: 32937107

5.Cellular entry of Hantaan virus A9 strain: specific interactions with beta3 integrins and a novel 70kDa protein. Mou DL, Wang YP, Huang CX, Li GY, Pan L, Yang WS, Bai XF. Biochem. Biophys. Res. Commun. 339, 611-7, (2006). PMID: 16310165

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