F
IPR002591

Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

InterPro entry
Short namePhosphodiest/P_Trfase
Overlapping
homologous
superfamilies
 
family relationships

Description

This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1/alkaline phosphodiesterase I/nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulphate bonds in NAD, deoxynucleotides and nucleotide sugars
[1, 10]
. Another member of this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity
[2, 9]
. The alignment encompasses the active site
[3, 2]
. Also present within this family is 60kDa Ca2-ATPase from Myroides odoratus
[4]
.

This entry also hits a number of ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis
[8, 7]
.

N-acetylglucosamine-6-O-sulfatase is another member of this family that catalyses the hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units and plays a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the gastrointestinal tract
[5, 6]
.

References

1.Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes. Jin-Hua P, Goding JW, Nakamura H, Sano K. Genomics 45, 412-5, (1997). View articlePMID: 9344668

2.cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. Murata J, Lee HY, Clair T, Krutzsch HC, Arestad AA, Sobel ME, Liotta LA, Stracke ML. J. Biol. Chem. 269, 30479-84, (1994). View articlePMID: 7982964

3.Affinity purification and cDNA cloning of rat neural differentiation and tumor cell surface antigen gp130RB13-6 reveals relationship to human and murine PC-1. Deissler H, Lottspeich F, Rajewsky MF. J. Biol. Chem. 270, 9849-55, (1995). View articlePMID: 7730366

4.Cloning and expression of the unique Ca2+-ATPase from Flavobacterium odoratum. Peiffer WE, Desrosiers MG, Menick DR. J. Biol. Chem. 271, 5095-100, (1996). View articlePMID: 8617788

5.Characterization of glycosaminoglycan (GAG) sulfatases from the human gut symbiont Bacteroides thetaiotaomicron reveals the first GAG-specific bacterial endosulfatase. Ulmer JE, Vilen EM, Namburi RB, Benjdia A, Beneteau J, Malleron A, Bonnaffe D, Driguez PA, Descroix K, Lassalle G, Le Narvor C, Sandstrom C, Spillmann D, Berteau O. J Biol Chem 289, 24289-303, (2014). View articlePMID: 25002587

6.How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. Cartmell A, Lowe EC, Basle A, Firbank SJ, Ndeh DA, Murray H, Terrapon N, Lombard V, Henrissat B, Turnbull JE, Czjzek M, Gilbert HJ, Bolam DN. Proc Natl Acad Sci U S A 114, 7037-7042, (2017). PMID: 28630303

7.Phenotype-genotype correlations of PIGO deficiency with variable phenotypes from infantile lethality to mild learning difficulties. Tanigawa J, Mimatsu H, Mizuno S, Okamoto N, Fukushi D, Tominaga K, Kidokoro H, Muramatsu Y, Nishi E, Nakamura S, Motooka D, Nomura N, Hayasaka K, Niihori T, Aoki Y, Nabatame S, Hayakawa M, Natsume J, Ozono K, Kinoshita T, Wakamatsu N, Murakami Y. Hum. Mutat. 38, 805-815, (2017). View articlePMID: 28337824

8.GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. Shishioh N, Hong Y, Ohishi K, Ashida H, Maeda Y, Kinoshita T. J. Biol. Chem. 280, 9728-34, (2005). View articlePMID: 15632136

9.Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. Tokumura A, Majima E, Kariya Y, Tominaga K, Kogure K, Yasuda K, Fukuzawa K. J Biol Chem 277, 39436-42, (2002). PMID: 12176993

10.Structural basis for nucleotide recognition by the ectoenzyme CD203c. Gorelik A, Randriamihaja A, Illes K, Nagar B. FEBS J 285, 2481-2494, (2018). PMID: 29717535

Cross References

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