D
IPR002761

Diphthamide synthase domain

InterPro entry
Short nameDiphthami_syn_dom
Overlapping
homologous
superfamilies
 

Description

Diphthamide_syn, diphthamide synthase, catalyses the last amidation step of diphthamide biosynthesis using ammonium and ATP. Diphthamide synthase is evolutionarily conserved in eukaryotes. Diphthamide is a post-translationally modified histidine residue found on archaeal and eukaryotic translation elongation factor 2 (eEF-2)
[1]
.

This domain has a strongly conserved motif SXGXDS at the N terminus
[2]
.

References

1.Chemogenomic approach identified yeast YLR143W as diphthamide synthetase. Su X, Lin Z, Chen W, Jiang H, Zhang S, Lin H. Proc. Natl. Acad. Sci. U.S.A. 109, 19983-7, (2012). View articlePMID: 23169644

2.Monophyly of class I aminoacyl tRNA synthetase, USPA, ETFP, photolyase, and PP-ATPase nucleotide-binding domains: implications for protein evolution in the RNA. Aravind L, Anantharaman V, Koonin EV. Proteins 48, 1-14, (2002). View articlePMID: 12012333

Cross References

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