IPR002761
Diphthamide synthase domain
InterPro entry
Short name | Diphthami_syn_dom |
Overlapping homologous superfamilies |
Description
Diphthamide_syn, diphthamide synthase, catalyses the last amidation step of diphthamide biosynthesis using ammonium and ATP. Diphthamide synthase is evolutionarily conserved in eukaryotes. Diphthamide is a post-translationally modified histidine residue found on archaeal and eukaryotic translation elongation factor 2 (eEF-2)
[1].
References
1.Chemogenomic approach identified yeast YLR143W as diphthamide synthetase. Su X, Lin Z, Chen W, Jiang H, Zhang S, Lin H. Proc. Natl. Acad. Sci. U.S.A. 109, 19983-7, (2012). View articlePMID: 23169644
2.Monophyly of class I aminoacyl tRNA synthetase, USPA, ETFP, photolyase, and PP-ATPase nucleotide-binding domains: implications for protein evolution in the RNA. Aravind L, Anantharaman V, Koonin EV. Proteins 48, 1-14, (2002). View articlePMID: 12012333
Cross References
ENZYME