IPR002869
Pyruvate-flavodoxin oxidoreductase, central domain
InterPro entry
Short name | Pyrv_flavodox_OxRed_cen |
Overlapping entries |
Description
This superfamily represents a domain found in prokaryotes. It includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether the gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyses the final step in the fermentation of carbohydrates in anaerobic microorganisms
[1]. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA
[1]. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited
[2].
References
1.Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima. Kletzin A, Adams MW. J. Bacteriol. 178, 248-57, (1996). View articlePMID: 8550425
2.Growth of the cyanobacterium Anabaena on molecular nitrogen: NifJ is required when iron is limited. Bauer CC, Scappino L, Haselkorn R. Proc. Natl. Acad. Sci. U.S.A. 90, 8812-6, (1993). View articlePMID: 8415612
GO terms
Cross References
Contributing Member Database Entries
- SUPERFAMILY:SSF53323
- CATH-Gene3D:G3DSA:3.40.920.10