Small GTPase Rho
Short name | Small_GTPase_Rho |
Overlapping homologous superfamilies | |
family relationships |
Description
* Arf small GTPases. GTP-binding proteins involved in protein trafficking by modulating vesicle budding and uncoating within the Golgi apparatus.
* Ran small GTPases. GTP-binding proteins involved in nucleocytoplasmic transport. Required for the import of proteins into the nucleus and also for RNA export.
* Rab small GTPases. GTP-binding proteins involved in vesicular traffic.
* Rho small GTPases. GTP-binding proteins that control cytoskeleton reorganisation.
* Ras small GTPases. GTP-binding proteins involved in signalling pathways.
* Sar1 small GTPases. Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).
* Mitochondrial Rho (Miro). Small GTPase domain found in mitochondrial proteins involved in mitochondrial trafficking.
* Roc small GTPases domain. Small GTPase domain always found associated with the COR domain.
References
1.Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nassar N, Hoffman GR, Manor D, Clardy JC, Cerione RA. Nat. Struct. Biol. 5, 1047-52, (1998). View articlePMID: 9846874
2.Crystal structure of Rnd3/RhoE: functional implications. Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR. FEBS Lett. 525, 100-4, (2002). View articlePMID: 12163169
3.MgF(3)(-) as a transition state analog of phosphoryl transfer. Graham DL, Lowe PN, Grime GW, Marsh M, Rittinger K, Smerdon SJ, Gamblin SJ, Eccleston JF. Chem. Biol. 9, 375-81, (2002). View articlePMID: 11927263
4.The GTPase superfamily: a conserved switch for diverse cell functions. Bourne HR, Sanders DA, McCormick F. Nature 348, 125-32, (1990). View articlePMID: 2122258
5.The GTPase superfamily: conserved structure and molecular mechanism. Bourne HR, Sanders DA, McCormick F. Nature 349, 117-27, (1991). View articlePMID: 1898771
6.The ras protein family: evolutionary tree and role of conserved amino acids. Valencia A, Chardin P, Wittinghofer A, Sander C. Biochemistry 30, 4637-48, (1991). View articlePMID: 2029511
7.Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. Pai EF, Krengel U, Petsko GA, Goody RS, Kabsch W, Wittinghofer A. EMBO J. 9, 2351-9, (1990). View articlePMID: 2196171
8.Structure of small G proteins and their regulators. Paduch M, Jelen F, Otlewski J. Acta Biochim. Pol. 48, 829-50, (2001). PMID: 11995995
9.Arabidopsis thaliana circadian clock is regulated by the small GTPase LIP1. Kevei E, Gyula P, Feher B, Toth R, Viczian A, Kircher S, Rea D, Dorjgotov D, Schafer E, Millar AJ, Kozma-Bognar L, Nagy F. Curr. Biol. 17, 1456-64, (2007). View articlePMID: 17683937
GO terms
biological process
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- PANTHER:PTHR24072