D
IPR003598

Immunoglobulin subtype 2

InterPro entry
Short nameIg_sub2
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry represents a subtype of the immunoglobulin domain, and is found in a diverse range of protein families that includes glycoproteins, fibroblast growth factor receptors, vascular endothelial growth factor receptors, interleukin-6 receptor, and neural cell adhesion molecules
[1]
.

The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable;
IPR013106
), C1-set (constant-1;
IPR003597
), C2-set (constant-2;
IPR008424
) and I-set (intermediate;
IPR013098
)
[4]
. Structural studies have shown that these domains share a common core Greek-key β-sandwich structure, with the types differing in the number of strands in the β-sheets as well as in their sequence patterns
[2, 3]
.

Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions, including cell-cell recognition, cell-surface receptors, muscle structure and the immune system
[5]
.

References

1.Evolutionary families of peptidase inhibitors. Rawlings ND, Tolle DP, Barrett AJ. Biochem. J. 378, 705-16, (2004). View articlePMID: 14705960

2.Protein--protein recognition: juxtaposition of domain and interface cores in immunoglobulins and other sandwich-like proteins. Potapov V, Sobolev V, Edelman M, Kister A, Gelfand I. J. Mol. Biol. 342, 665-79, (2004). View articlePMID: 15327963

3.Mapping the folding pathway of an immunoglobulin domain: structural detail from Phi value analysis and movement of the transition state. Fowler SB, Clarke J. Structure 9, 355-66, (2001). View articlePMID: 11377196

4.Sequence profiles of immunoglobulin and immunoglobulin-like domains. Smith DK, Xue H. J. Mol. Biol. 274, 530-45, (1997). View articlePMID: 9417933

5.Immunoglobulin superfamily proteins in Caenorhabditis elegans. Teichmann SA, Chothia C. J. Mol. Biol. 296, 1367-83, (2000). View articlePMID: 10698639

Cross References

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