IPR004299
Membrane bound O-acyl transferase, MBOAT
InterPro entry
Short name | MBOAT_fam |
family relationships |
Description
This family includes Diacylglycerol O-acyltransferase 1 (DGAT1) and Lysophospholipid acyltransferase 7 (MBOAT7) from humans. DGAT1 catalyses the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates
[3]. It also functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders
[3]. MBOAT7 participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation
[2].
References
1.A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling. Hofmann K. Trends Biochem. Sci. 25, 111-2, (2000). View articlePMID: 10694878
2.LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover. Tanaka Y, Shimanaka Y, Caddeo A, Kubo T, Mao Y, Kubota T, Kubota N, Yamauchi T, Mancina RM, Baselli G, Luukkonen P, Pihlajamaki J, Yki-Jarvinen H, Valenti L, Arai H, Romeo S, Kono N. Gut 70, 180-193, (2021). PMID: 32253259
Cross References
Contributing Member Database Entry
- Pfam:PF03062