F
IPR004299

Membrane bound O-acyl transferase, MBOAT

InterPro entry
Short nameMBOAT_fam
family relationships

Description

The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue
[1]
. The structure of MBOAT has been revealed
[4]
.

This family includes Diacylglycerol O-acyltransferase 1 (DGAT1) and Lysophospholipid acyltransferase 7 (MBOAT7) from humans. DGAT1 catalyses the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates
[3]
. It also functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders
[3]
. MBOAT7 participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation
[2]
.

References

1.A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling. Hofmann K. Trends Biochem. Sci. 25, 111-2, (2000). View articlePMID: 10694878

2.LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover. Tanaka Y, Shimanaka Y, Caddeo A, Kubo T, Mao Y, Kubota T, Kubota N, Yamauchi T, Mancina RM, Baselli G, Luukkonen P, Pihlajamaki J, Yki-Jarvinen H, Valenti L, Arai H, Romeo S, Kono N. Gut 70, 180-193, (2021). PMID: 32253259

3.Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1. Orland MD, Anwar K, Cromley D, Chu CH, Chen L, Billheimer JT, Hussain MM, Cheng D. Biochim Biophys Acta 1737, 76-82, (2005). PMID: 16214399

4.Crystal structure of a membrane-bound O-acyltransferase. Ma D, Wang Z, Merrikh CN, Lang KS, Lu P, Li X, Merrikh H, Rao Z, Xu W. Nature 562, 286-290, (2018). PMID: 30283133

Cross References

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