Otopetrin
Short name | Otopetrin |
Description
References
1.Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members. Hughes I, Binkley J, Hurle B, Green ED; NISC Comparative Sequencing Program, Sidow A, Ornitz DM. BMC Evol. Biol. 8, 41, (2008). View articlePMID: 18254951
2.An evolutionarily conserved gene family encodes proton-selective ion channels. Tu YH, Cooper AJ, Teng B, Chang RB, Artiga DJ, Turner HN, Mulhall EM, Ye W, Smith AD, Liman ER. Science 359, 1047-1050, (2018). PMID: 29371428
3.Structures of the otopetrin proton channels Otop1 and Otop3. Saotome K, Teng B, Tsui CCA, Lee WH, Tu YH, Kaplan JP, Sansom MSP, Liman ER, Ward AB. Nat Struct Mol Biol 26, 518-525, (2019). PMID: 31160780
Further reading
6. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Hurle B, Ignatova E, Massironi SM, Mashimo T, Rios X, Thalmann I, Thalmann R, Ornitz DM. Hum Mol Genet 12, 777-89, (2003). PMID: 12651873
7. Sour Sensing from the Tongue to the Brain. Zhang J, Jin H, Zhang W, Ding C, O'Keeffe S, Ye M, Zuker CS. Cell 179, 392-402.e15, (2019). PMID: 31543264
8. Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1. Teng B, Wilson CE, Tu YH, Joshi NR, Kinnamon SC, Liman ER. Curr Biol 29, 3647-3656.e5, (2019). PMID: 31543453
GO terms
biological process
molecular function
cellular component