F
IPR004878

Otopetrin

InterPro entry
Short nameOtopetrin

Description

The otopetrins are a group of proteins evolutionarily conserved among metazoan
[1]
. In most vertebrates there are three Otopetrin genes that encode three proteins, OTOP1, OTOP2, and OTOP3. All form proton-selective ion channels that allow influx of protons into cells
[2]
. The structure of otopetrin-1 (
Q80VM9
) shows it to have 12 transmembrane domains, with three conserved sub-domains (OD-1 to OD-III)
[1, 3, 4]
. Otopetrins were initially thought to modulate calcium homeostasis and influx of calcium in response to extracellular ATP
[5]
but were subsequently shown to form proton-selective ion channels
[2]
.

References

1.Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members. Hughes I, Binkley J, Hurle B, Green ED; NISC Comparative Sequencing Program, Sidow A, Ornitz DM. BMC Evol. Biol. 8, 41, (2008). View articlePMID: 18254951

2.An evolutionarily conserved gene family encodes proton-selective ion channels. Tu YH, Cooper AJ, Teng B, Chang RB, Artiga DJ, Turner HN, Mulhall EM, Ye W, Smith AD, Liman ER. Science 359, 1047-1050, (2018). PMID: 29371428

3.Structures of the otopetrin proton channels Otop1 and Otop3. Saotome K, Teng B, Tsui CCA, Lee WH, Tu YH, Kaplan JP, Sansom MSP, Liman ER, Ward AB. Nat Struct Mol Biol 26, 518-525, (2019). PMID: 31160780

4.Structural and functional characterization of an otopetrin family proton channel. Chen Q, Zeng W, She J, Bai XC, Jiang Y. Elife 8, (2019). PMID: 30973323

5.Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium. Hughes I, Saito M, Schlesinger PH, Ornitz DM. Proc Natl Acad Sci U S A 104, 12023-8, (2007). PMID: 17606897

Further reading

6. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Hurle B, Ignatova E, Massironi SM, Mashimo T, Rios X, Thalmann I, Thalmann R, Ornitz DM. Hum Mol Genet 12, 777-89, (2003). PMID: 12651873

7. Sour Sensing from the Tongue to the Brain. Zhang J, Jin H, Zhang W, Ding C, O'Keeffe S, Ye M, Zuker CS. Cell 179, 392-402.e15, (2019). PMID: 31543264

8. Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1. Teng B, Wilson CE, Tu YH, Joshi NR, Kinnamon SC, Liman ER. Curr Biol 29, 3647-3656.e5, (2019). PMID: 31543453

GO terms

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