D
IPR006124

Metalloenzyme

InterPro entry
Short nameMetalloenzyme
Overlapping
homologous
superfamilies
 

Description

This domain unites alkaline phosphatase, N-acetylgalactosamine-4-sulphatase, and cerebroside sulphatase, enzymes with known three-dimensional structures, with phosphopentomutase, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, phosphoglycerol transferase, phosphonate monoesterase, streptomycin-6-phosphate phosphatase, alkaline phosphodiesterase/nucleotide pyrophosphatase PC-1, and several closely related sulphatases. This domain is also related to alkaline phosphatase
IPR001952
[1]
. The most conserved residues are probably involved in metal binding and catalysis.

References

1.A superfamily of metalloenzymes unifies phosphopentomutase and cofactor-independent phosphoglycerate mutase with alkaline phosphatases and sulfatases. Galperin MY, Bairoch A, Koonin EV. Protein Sci. 7, 1829-35, (1998). View articlePMID: 10082381

GO terms

biological process

  • None

cellular component

  • None

Cross References

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