F
IPR006143

RND efflux pump, membrane fusion protein

InterPro entry
Short nameRND_pump_MFP
family relationships

Description

This entry represents a large family of polypeptides, the MFP (for membrane fusion protein) family. MFPs are a component of the RND family of transporters (RND refers to resistance, nodulation, and cell division). MFPs are proposed to span the periplasm in some way linking the inner and outer membranes
[2]
. However, some members of this family are found in Gram-positive bacteria, where there is no outer membrane. MFPs are involved in the export of a variety of compounds, from drug molecules to large polypeptides, and are united by their similar overall structural organisation, combined with some conserved regions
[1]
.

References

1.Mutations in HlyD, part of the type 1 translocator for hemolysin secretion, affect the folding of the secreted toxin. Pimenta AL, Racher K, Jamieson L, Blight MA, Holland IB. J. Bacteriol. 187, 7471-80, (2005). View articlePMID: 16237030

2.A topological model for the haemolysin translocator protein HlyD. Schulein R, Gentschev I, Mollenkopf HJ, Goebel W. Mol. Gen. Genet. 234, 155-63, (1992). PMID: 1495479

Further reading

3. Genetic analysis of an MDR-like export system: the secretion of colicin V. Gilson L, Mahanty HK, Kolter R. EMBO J. 9, 3875-84, (1990). View articlePMID: 2249654

4. Protease secretion by Erwinia chrysanthemi: the specific secretion functions are analogous to those of Escherichia coli alpha-haemolysin. Letoffe S, Delepelaire P, Wandersman C. EMBO J. 9, 1375-82, (1990). View articlePMID: 2184029

5. Molecular analyses of the lactococcin A gene cluster from Lactococcus lactis subsp. lactis biovar diacetylactis WM4. Stoddard GW, Petzel JP, van Belkum MJ, Kok J, McKay LL. Appl. Environ. Microbiol. 58, 1952-61, (1992). View articlePMID: 1622271

6. Sequence of a cluster of genes controlling synthesis and secretion of alkaline protease in Pseudomonas aeruginosa: relationships to other secretory pathways. Duong F, Lazdunski A, Cami B, Murgier M. Gene 121, 47-54, (1992). View articlePMID: 1427098

7. Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa. Akama H, Matsuura T, Kashiwagi S, Yoneyama H, Narita S, Tsukihara T, Nakagawa A, Nakae T. J. Biol. Chem. 279, 25939-42, (2004). View articlePMID: 15117957

GO terms

Cross References

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