Peptidase S24, LexA-like
Short name | Peptidase_S24_LexA |
Overlapping homologous superfamilies | |
family relationships |
Description
* LexA, the repressor of genes in the cellular SOS response to DNA damage
* MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage
* RumA a plasmid encoded homologue of UmuD
* RuvA, which is a component of the RuvABC resolvasome that catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair
References
1.Analysis of Escherichia coli RecA interactions with LexA, lambda CI, and UmuD by site-directed mutagenesis of recA. Mustard JA, Little JW. J. Bacteriol. 182, 1659-70, (2000). View articlePMID: 10692372
2.Converting a DNA damage checkpoint effector (UmuD2C) into a lesion bypass polymerase (UmuD'2C). Ferentz AE, Walker GC, Wagner G. EMBO J. 20, 4287-98, (2001). View articlePMID: 11483531
3.The RuvABC resolvasome. Dickman MJ, Ingleston SM, Sedelnikova SE, Rafferty JB, Lloyd RG, Grasby JA, Hornby DP. Eur. J. Biochem. 269, 5492-501, (2002). View articlePMID: 12423347
4.Plasmid-encoded MucB protein is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA', RecA, and SSB. Goldsmith M, Sarov-Blat L, Livneh Z. Proc. Natl. Acad. Sci. U.S.A. 97, 11227-31, (2000). View articlePMID: 11016960
5.Intermolecular cleavage by UmuD-like enzymes: identification of residues required for cleavage and substrate specificity. McDonald JP, Peat TS, Levine AS, Woodgate R. J. Mol. Biol. 285, 2199-209, (1999). View articlePMID: 9925794
6.Analysis of the mutagenic properties of the UmuDC, MucAB and RumAB proteins, using a site-specific abasic lesion. Lawrence CW, Borden A, Woodgate R. Mol. Gen. Genet. 251, 493-8, (1996). View articlePMID: 8709953
7.Genetic and biochemical characterization of a novel umuD mutation: insights into a mechanism for UmuD self-cleavage. Sutton MD, Kim M, Walker GC. J. Bacteriol. 183, 347-57, (2001). View articlePMID: 11114935
GO terms
biological process
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- PRINTS:PR00726