D
IPR006683

Thioesterase domain

InterPro entry
Short nameThioestr_dom
Overlapping
homologous
superfamilies
 
domain relationships

Description

A wide variety of enzymes contain this domain, principally thioesterases. Proteins containing this domain include 4HBT (4-hydroxybenzoyl-CoA thioesterase) (
3.1.2.23
) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3
[1, 3]
. It also includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters
[2]
.

References

1.The three-dimensional structure of 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. Strain CBS-3. Benning MM, Wesenberg G, Liu R, Taylor KL, Dunaway-Mariano D, Holden HM. J. Biol. Chem. 273, 33572-9, (1998). View articlePMID: 9837940

2.Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site. Leesong M, Henderson BS, Gillig JR, Schwab JM, Smith JL. Structure 4, 253-64, (1996). View articlePMID: 8805534

3.Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3. Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D. Biochemistry 31, 5605-10, (1992). View articlePMID: 1610806

Cross References

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