F
IPR006952

Retinal cGMP phosphodiesterase, gamma subunit

InterPro entry
Short namePDE6_gamma
Overlapping
homologous
superfamilies
 

Description

Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit
[1]
, which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells
[2]
.

References

1.Direct interaction of the inhibitory gamma-subunit of Rod cGMP phosphodiesterase (PDE6) with the PDE6 GAFa domains. Muradov KG, Granovsky AE, Schey KL, Artemyev NO. Biochemistry 41, 3884-90, (2002). View articlePMID: 11900530

2.The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. Wan KF, Sambi BS, Frame M, Tate R, Pyne NJ. J. Biol. Chem. 276, 37802-8, (2001). View articlePMID: 11502744

GO terms

Cross References

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