IPR006952
Retinal cGMP phosphodiesterase, gamma subunit
InterPro entry
Short name | PDE6_gamma |
Overlapping homologous superfamilies |
Description
Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit
[1], which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells
[2].
References
1.Direct interaction of the inhibitory gamma-subunit of Rod cGMP phosphodiesterase (PDE6) with the PDE6 GAFa domains. Muradov KG, Granovsky AE, Schey KL, Artemyev NO. Biochemistry 41, 3884-90, (2002). View articlePMID: 11900530
2.The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. Wan KF, Sambi BS, Frame M, Tate R, Pyne NJ. J. Biol. Chem. 276, 37802-8, (2001). View articlePMID: 11502744
GO terms
biological process
molecular function
cellular component
- None
Cross References
ENZYME
Contributing Member Database Entries
- Pfam:PF04868
- PIRSF:PIRSF000969
- PANTHER:PTHR12122