D
IPR007120

DNA-directed RNA polymerase, subunit 2, hybrid-binding domain

InterPro entry
Short nameDNA-dir_RNAP_su2_dom
Overlapping
homologous
superfamilies
 

Description

RNA polymerases (
2.7.7.6
) catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain represents the hybrid-binding domain and the wall domain
[1]
. The hybrid-binding domain binds the nascent RNA strand/template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion
[1]
. This domain is also involved in binding to Rpb1 and Rpb3
[1]
. Many of the bacterial members contain large insertions within this domain, which are known as dispensable region 2 (DRII).

References

1.Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Cramer P, Bushnell DA, Kornberg RD. Science 292, 1863-76, (2001). View articlePMID: 11313498

GO terms

Cross References

Contributing Member Database Entry
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