F
IPR007528

RINT-1/Tip20

InterPro entry
Short nameRINT1_Tip20
Overlapping
homologous
superfamilies
 

Description

This entry includes RINT-1 from animals, Tip20 from yeasts and MAIGO2 (Mag2) from plants. They play a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity
[7]
. They are part of the CATCHR (complexes associated with tethering containing helical rods) family which comprises the exocyst, COG, GARP, and DSL1 complexes and share a similar structure organisation with an N-terminal coiled-coil and a C-terminal α-helical bundle, which might be a protein-protein interaction module necessary for the formation of functional complexes.

RINT-1 interacts with Rad50 only during late S and G2/M phases and participates in radiation induced checkpoint control
[2]
. RINT-1 also functions in membrane trafficking from the endoplasmic reticulum (ER) to the Golgi complex in interphase cells
[2, 5, 6]
.

Tip20 is involved in the retrograde transport from the Golgi to the ER
[4, 1]
.

Arabidopsis Mag2 functions in the transport of storage protein precursors between the ER and Golgi complex in plants
[3, 8]
.

References

1.The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p. Sweet DJ, Pelham HR. EMBO J. 12, 2831-40, (1993). View articlePMID: 8334998

2.RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control. Xiao J, Liu CC, Chen PL, Lee WH. J. Biol. Chem. 276, 6105-11, (2001). View articlePMID: 11096100

3.MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana. Li L, Shimada T, Takahashi H, Ueda H, Fukao Y, Kondo M, Nishimura M, Hara-Nishimura I. Plant Cell 18, 3535-47, (2006). View articlePMID: 17194767

4.Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Tripathi A, Ren Y, Jeffrey PD, Hughson FM. Nat. Struct. Mol. Biol. 16, 114-23, (2009). View articlePMID: 19151722

5.The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. Kong LJ, Meloni AR, Nevins JR. Mol. Cell 22, 63-71, (2006). View articlePMID: 16600870

6.RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. Arasaki K, Taniguchi M, Tani K, Tagaya M. Mol. Biol. Cell 17, 2780-8, (2006). View articlePMID: 16571679

7.Homology and Modular Evolution of CATCHR at the Origin of the Eukaryotic Endomembrane System. Santana-Molina C, Gutierrez F, Devos DP. Genome Biol Evol 13, (2021). PMID: 34061181

8.MAG2 and three MAG2-INTERACTING PROTEINs form an ER-localized complex to facilitate storage protein transport in Arabidopsis thaliana. Li L, Shimada T, Takahashi H, Koumoto Y, Shirakawa M, Takagi J, Zhao X, Tu B, Jin H, Shen Z, Han B, Jia M, Kondo M, Nishimura M, Hara-Nishimura I. Plant J. 76, 781-91, (2013). View articlePMID: 24118572

GO terms

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