D
IPR007887

NTF2-like N-terminal transpeptidase

InterPro entry
Short nameMecA_N

Description

The multiple antibiotic resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) has become a major clinical problem worldwide. Methicillin resistance in MRSA strains is due to the acquisition of the mecA gene via horizontal transfer from an unidentified species which encodes penicillin-binding protein 2a (PBP2a).

References

1. Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Lim D, Strynadka NC. Nat. Struct. Biol. 9, 870-6, (2002). PMID: 12389036

GO terms

molecular function

  • None

cellular component

  • None

Cross References

Contributing Member Database Entry
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