IPR007887
NTF2-like N-terminal transpeptidase
InterPro entry
Short name | MecA_N |
Description
The multiple antibiotic resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) has become a major clinical problem worldwide. Methicillin resistance in MRSA strains is due to the acquisition of the mecA gene via horizontal transfer from an unidentified species which encodes penicillin-binding protein 2a (PBP2a).
References
1. Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Lim D, Strynadka NC. Nat. Struct. Biol. 9, 870-6, (2002). PMID: 12389036
GO terms
Cross References
ENZYME
Contributing Member Database Entry
- Pfam:PF05223