D
IPR008030

NmrA-like domain

InterPro entry
Short nameNmrA-like
Overlapping
homologous
superfamilies
 
domain relationships

Description

NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA
[2]
. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. It lacks most of the active site residues of the SDR (short-chain dehydrogenases/reductases) family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG
[1]
.

This domain can also be found in other atypical SDRs, such as HSCARG (an NADPH sensor)
[4]
and PCBER (phenylcoumaran benzylic ether reductase)
[3]
.

References

1.The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases. Stammers DK, Ren J, Leslie K, Nichols CE, Lamb HK, Cocklin S, Dodds A, Hawkins AR. EMBO J. 20, 6619-26, (2001). View articlePMID: 11726498

2.Structural analysis of the recognition of the negative regulator NmrA and DNA by the zinc finger from the GATA-type transcription factor AreA. Kotaka M, Johnson C, Lamb HK, Hawkins AR, Ren J, Stammers DK. J. Mol. Biol. 381, 373-82, (2008). View articlePMID: 18602114

3.Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases and their relationship to isoflavone reductases. Min T, Kasahara H, Bedgar DL, Youn B, Lawrence PK, Gang DR, Halls SC, Park H, Hilsenbeck JL, Davin LB, Lewis NG, Kang C. J. Biol. Chem. 278, 50714-23, (2003). View articlePMID: 13129921

4.An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. Zhao Y, Zhang J, Li H, Li Y, Ren J, Luo M, Zheng X. J. Biol. Chem. 283, 11004-13, (2008). PMID: 18263583

Cross References

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