F
IPR008911

Short scorpion toxin, potassium channel inhibitor alpha-KTx 8/9

InterPro entry
Short nameToxin_alpha-KTx_8/9
Overlapping
homologous
superfamilies
 

Description

Scorpion toxins that target K+ channels (KTx) have been classified into four large families: alpha, beta, gamma and kappa-KTx
[1]
. This family consists of toxin-like peptides from the alpha-KTx 8 and alpha-KTx 9 subfamilies. The precursor of these toxins consists of 60 amino acid residues, with a putative signal peptide of 28 residues and an extra residue, and a mature peptide of 31 residues with an amidated C-terminal. The peptides share close homology with other scorpion K+ channel toxins and should present a common three-dimensional fold - the Cysteine -Stabilised alphabeta (CSalphabeta) motif
[2]
. This family acts by blocking small conductance calcium activated potassium ion channels in their victim
[3, 4]
.

References

1.Current views on scorpion toxins specific for K+-channels. Rodriguez de la Vega RC, Possani LD. Toxicon 43, 865-75, (2004). View articlePMID: 15208019

2.Precursor nucleotide sequence and genomic organization of BmTXKS1, a new scorpion toxin-like peptide from Buthus martensii Karsch. Zhu SY, Li WX, Zeng XC. Toxicon 39, 1291-6, (2001). View articlePMID: 11384716

3.Solution structure of BmP02, a new potassium channel blocker from the venom of the Chinese scorpion Buthus martensi Karsch. Xu Y, Wu J, Pei J, Shi Y, Ji Y, Tong Q. Biochemistry 39, 13669-75, (2000). View articlePMID: 11076505

4.Molecular cloning and sequencing of two 'short chain' and two 'long chain' K(+) channel-blocking peptides from the Chinese scorpion Buthus martensii Karsch. Zhu S, Li W, Zeng X, Jiang D, Mao X, Liu H. FEBS Lett. 457, 509-14, (1999). View articlePMID: 10471839

GO terms

biological process

  • None
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