H
IPR008979

Galactose-binding-like domain superfamily

InterPro entry
Short nameGalactose-bd-like_sf
Overlapping entries
 
P domain (IPR002884)

Description

Proteins containing a galactose-binding-like domain fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase
[1]
, phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va
[2]
, membrane-anchored ephrin for the Eph family of receptor tyrosine kinases
[3]
, and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1
[4]
.

The structure of the galactose-binding-like domain members consists of a β-sandwich, in which the strands making up the sheets exhibit a jelly roll fold. There is a high degree of similarity in the β-sandwich and in the loops between different family members, despite an often low level of sequence similarity.

References

1.Novel thioether bond revealed by a 1.7 A crystal structure of galactose oxidase. Ito N, Phillips SE, Stevens C, Ogel ZB, McPherson MJ, Keen JN, Yadav KD, Knowles PF. Nature 350, 87-90, (1991). View articlePMID: 2002850

2.Crystal structures of the membrane-binding C2 domain of human coagulation factor V. Macedo-Ribeiro S, Bode W, Huber R, Quinn-Allen MA, Kim SW, Ortel TL, Bourenkov GP, Bartunik HD, Stubbs MT, Kane WH, Fuentes-Prior P. Nature 402, 434-9, (1999). View articlePMID: 10586886

3.Crystal structure of an Eph receptor-ephrin complex. Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB. Nature 414, 933-8, (2001). View articlePMID: 11780069

4.Solution structure of the single-strand break repair protein XRCC1 N-terminal domain. Marintchev A, Mullen MA, Maciejewski MW, Pan B, Gryk MR, Mullen GP. Nat. Struct. Biol. 6, 884-93, (1999). View articlePMID: 10467102

Cross References

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