D
IPR009720

IMP biosynthesis enzyme PurP, C-terminal

InterPro entry
Short nameIMP_biosynth_PurP_C
domain relationships

Description

The last two steps ofde novopurine biosynthesis are:

     * conversion of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate (FAICAR)
     * conversion of FAICAR to inosine5'-monophopsphate (IMP)

In bacteria and eukaryotes, these steps are catalysed by the well-characterised bifunctional enzyme PurH
[1]
. Archaea do not appear to posses PurH, however, and perform these reactions by a different mechanism
[2]
. In archaea, step i) is catalysed by the well-conserved PurP protein, while step ii) is catalysed by the PurO enzyme in some (though not all) species
[3, 4]
.

This entry represents the C-terminal domain of PurP, which is homologous to the ATP-GRASP fold and thus may be involved in ATP-binding. It is almost always found in association with
IPR010672
.

References

1.Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. Greasley SE, Horton P, Ramcharan J, Beardsley GP, Benkovic SJ, Wilson IA. Nat. Struct. Biol. 8, 402-6, (2001). View articlePMID: 11323713

2.Purine biosynthesis in the domain Archaea without folates or modified folates. White RH. J. Bacteriol. 179, 3374-7, (1997). View articlePMID: 9150241

3.A Methanocaldococcus jannaschii archaeal signature gene encodes for a 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase. A new enzyme in purine biosynthesis. Ownby K, Xu H, White RH. J. Biol. Chem. 280, 10881-7, (2005). View articlePMID: 15623504

4.New class of IMP cyclohydrolases in Methanococcus jannaschii. Graupner M, Xu H, White RH. J. Bacteriol. 184, 1471-3, (2002). View articlePMID: 11844782

GO terms

Cross References

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.