IPR009878
Phlebovirus glycoprotein G2, fusion domain
InterPro entry
Short name | Phlebovirus_G2_fusion |
Description
HRTV is an insect-borne virus found in America that can infect humans. It belongs to the newly defined family Phenuiviridae, order Bunyavirales. HRTV contains three single-stranded RNA segments (L, M, and S). The M segment of the virus encodes a polyprotein precursor that is cleaved into two glycoproteins, Gn and Gc. Gc is a fusion protein facilitating virus entry into host cells
[2]. G2 (also known as Gc) is necessary for optimal glycoprotein G1 (also found as Gn) expression and efficient production or viral-like particles and possibly for the cell infection, as G2 is determinant for cell fusion
[1]. Phleboviral G2 fusion glycoprotein is both functionally and structurally analogous to the fusion glycoproteins of alphaviruses and flaviviruses, all of them recognize DC-SIGN receptor to enable viral attachment
[2].
This domain consists of the N-terminal and middle domains, known as fusion domain, of several Phlebovirus glycoprotein G2 sequences.
References
Contributing Member Database Entry
- Pfam:PF07245
Representative structure
4hj1: Crystal structure of glycoprotein C from Rift Valley Fever Virus (glycosylated)