D
IPR009878

Phlebovirus glycoprotein G2, fusion domain

InterPro entry
Short namePhlebovirus_G2_fusion

Description

HRTV is an insect-borne virus found in America that can infect humans. It belongs to the newly defined family Phenuiviridae, order Bunyavirales. HRTV contains three single-stranded RNA segments (L, M, and S). The M segment of the virus encodes a polyprotein precursor that is cleaved into two glycoproteins, Gn and Gc. Gc is a fusion protein facilitating virus entry into host cells
[2]
. G2 (also known as Gc) is necessary for optimal glycoprotein G1 (also found as Gn) expression and efficient production or viral-like particles and possibly for the cell infection, as G2 is determinant for cell fusion
[1]
. Phleboviral G2 fusion glycoprotein is both functionally and structurally analogous to the fusion glycoproteins of alphaviruses and flaviviruses, all of them recognize DC-SIGN receptor to enable viral attachment
[2]
.

This domain consists of the N-terminal and middle domains, known as fusion domain, of several Phlebovirus glycoprotein G2 sequences.

References

1.Efficient cellular release of Rift Valley fever virus requires genomic RNA. Piper ME, Sorenson DR, Gerrard SR. PLoS ONE 6, e18070, (2011). PMID: 21445316

2.Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion. Halldorsson S, Behrens AJ, Harlos K, Huiskonen JT, Elliott RM, Crispin M, Brennan B, Bowden TA. Proc. Natl. Acad. Sci. U.S.A. 113, 7154-9, (2016). PMID: 27325770

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.